The all-female reboot was so obsessed with being an all-female reboot that they forgot to take advantage of the three funniest women in America, a great script, and a wonderful idea.
Afterlife? Now, you know...that sort of plugs into the darker elements of the first two movies (the ghosts are on the rise because of the coming apocalypse and, thanks to the Og Ghostbusters, the apocalypse has been averted...or...has it?) So, done right, I would not object.