i've got chrome for my non-work tabs, ff for my work tabs, and IE(6) for work things which require either IE or a second browser's opinion.
Every so often something fails to load in chrome: for a few days, mail.google.com didn't load! Very odd like that. But yeah, since I always have ff and chrome up at the same time, it's easy for me not to notice the lack of add-ons. It just feels like I have a fast and sleek browser, and a slower one.